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Dye‐Labeled C α ‐Tetrasubstituted α ‐Amino Acids
Author(s) -
Dobmeier Michael,
Maity Prantik,
König Burkhard
Publication year - 2014
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201400139
Subject(s) - chemistry , pyrene , fluorescence , amino acid , sequence (biology) , stereochemistry , peptide , peptide bond , fluorescein , organic chemistry , biochemistry , physics , quantum mechanics
We report the synthesis of pyrene‐ and carboxyfluorescein labeled C α ‐tetrasubstituted amino acids (TAAs). The fluorescent dye can be coupled to the TAA before or after its incorporation into a peptide sequence using a Suzuki ‐type CC bond formation.