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Stereoselective Total Synthesis of the Natural Oxylipin (6 R ,7 E ,9 R ,10 S )‐6,9,10‐Trihydroxyoctadec‐7‐enoic Acid
Author(s) -
Salva Reddy N.,
Das Biswanath
Publication year - 2015
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201400131
Subject(s) - oxylipin , chemistry , stereoselectivity , total synthesis , olefin metathesis , stereochemistry , nonanal , kinetic resolution , olefin fiber , diol , metathesis , organic chemistry , enantioselective synthesis , catalysis , polymer , polymerization , enzyme
The stereoselective total synthesis of the natural oxylipin, (6 R ,7 E ,9 R ,10 S )‐6,9,10‐trihydroxyoctadec‐7‐enoic acid, has been accomplished using nonanal and hexane‐1,6‐diol as the starting materials. The synthesis involves Sharpless kinetic resolution, asymmetric epoxidation, and olefin cross‐metathesis as the key steps.