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Secondary Metabolites from the Endophytic Fungus Xylaria cubensis
Author(s) -
Fan NaiWen,
Chang HsunShuo,
Cheng MingJen,
Hsieh SungYuan,
Liu TaWei,
Yuan GwoFang,
Chen IhSheng
Publication year - 2014
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201400091
Subject(s) - chemistry , isocoumarin , stereochemistry , lauraceae , fungus , terpenoid , two dimensional nuclear magnetic resonance spectroscopy , terpene , plant use of endophytic fungi in defense , metabolite , fermentation , organic chemistry , botany , biochemistry , biology
Seven new metabolites, including three sesquiterpenoids, 10‐hydroxythujopsene ( 1 ), akotriol ( 2 ), and xylaritriol ( 3 ), one diterpenoid, cubentriol ( 4 ), one aliphatic derivative, akoenic acid ( 5 ), one alkaloid, akodionine ( 6 ), and one isocoumarin, akolitserin ( 7 ), together with seven known compounds, 8 – 14 , were isolated from the AcOEt‐soluble fraction of the fermentation broth of the endophytic fungus Xylaria cubensis , derived from the leaves of Litsea akoensis Hayata (Lauraceae). Their structures were elucidated by spectroscopic analyses, including 1D‐ and 2D‐NMR experiments, and by HR‐ESI‐MS mass spectrometry. Among the isolates, (−)‐( R )‐7‐hydroxymellein showed IL‐6 inhibitory activity with an IC 50 value of 9.41 μ M .
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