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N‐Heterocyclic Carbene‐Catalyzed α ‐Alkylation of Ketones with Primary Alcohols
Author(s) -
Zhu Yanfang,
Cai Chun,
Lu Guoping
Publication year - 2014
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201400076
Subject(s) - chemistry , carbene , alkylation , catalysis , primary (astronomy) , base (topology) , organic chemistry , medicinal chemistry , mathematical analysis , physics , mathematics , astronomy
Several N‐heterocyclic carbene precursors are synthesized and used in the α ‐alkylations of ketones with primary alcohols. With the assistance of a base, these N‐heterocyclic carbenes can catalyze the reaction smoothly to furnish dialkylated ketones in good‐to‐excellent yields.