Premium
An Efficient Approach to the Synthesis of Hydrazinyl Pseudo ‐Peptides
Author(s) -
Fathi Vaezeh,
Ramezanpour Sorour,
Balalaie Saeed,
Rominger Frank,
Reza Bijanzadeh Hamid
Publication year - 2014
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201400061
Subject(s) - chemistry , atom economy , amide , component (thermodynamics) , peptide bond , combinatorial chemistry , bond , reaction conditions , atom (system on chip) , organic chemistry , amino acid , business , catalysis , biochemistry , finance , parallel computing , thermodynamics , physics , computer science
New hydrazinyl pseudo ‐peptides have been obtained from Ugi four‐component reaction (4CR). The 5‐hydrazinyl‐5‐oxopentanoic acids used as starting materials were prepared by the reaction of hydrazides with anhydrides. Mild reaction conditions, high atom economy, bond‐forming efficiency, and easy workup are advantages of this approach. The products have four amide bonds and high potential for H‐bonding.