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Synthesis of Furo[2,3‐ d ]pyridazin‐4(5 H )‐one and Its N(5) ‐Substituted Derivatives
Author(s) -
Karahan Emrah,
Koza Gani,
Balci Metin
Publication year - 2014
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201400042
Subject(s) - chemistry , hydrazine (antidepressant) , hydrolysis , aldehyde , carboxylate , group (periodic table) , medicinal chemistry , organic chemistry , stereochemistry , catalysis , chromatography
We report the efficient preparation of furo[2,3‐ d ]pyridazin‐4(5 H )‐one and its N ‐substituted derivatives starting from methyl 2‐methylfuran‐3‐carboxylate. The Me group was converted to the aldehyde group, which was then condensed with hydrazine derivatives. Then, the ester functionalities were hydrolyzed to the corresponding acids, followed by treatment with SOCl 2 to give N‐ substituted furopyridazinone derivatives.