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Lycopodium Alkaloids from Huperzia serrata
Author(s) -
Ying YouMin,
Liu XiaoSa,
Tong CuiPing,
Wang JianWei,
Zhan ZhaJun,
Shan WeiGuang
Publication year - 2014
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201400015
Subject(s) - lycopodium , huperzine a , chemistry , stereochemistry , acarbose , acetylcholinesterase , alkaloid , biochemistry , enzyme
Three new lycopodium alkaloids, huperserramines A–C ( 1 – 3 , resp.), along with 15 known ones, lycopodine‐6 α ,11 α ‐diol ( 4 ), lycoposerramine H ( 5 ), lycoposerramine I ( 6 ), lycopodine‐6 α ‐ol ( 7 ), lycoposerramine M ( 8 ), diphaladine A ( 9 ), lycoposerramine K ( 10 ), lycoposerramine W ( 11 ), huperzine M ( 12 ), luciduline ( 13 ), phlegmariuine N ( 14 ), huperzine A ( 15 ), huperzine B ( 16 ), lycodine ( 17 ), and lycoposerramine R ( 18 ), were isolated from the whole plant of Huperzia serrata. Their structures were established by spectroscopic methods, including 2D‐NMR and MS analyses. All the isolates were evaluated for their inhibitory effects on acetylcholinesterase (AChE) and α ‐glucosidase. As a result, lycopodine‐6 α ,11 α‐ diol ( 4 ) exhibited more potent α ‐glucosidase inhibitory activity ( IC 5 0 148±5.5 μ M ) than the positive control acarbose ( IC 50 376.3±2.7 μ M ).