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Sulfated Triterpenes from Lemon Balm
Author(s) -
Tantry Mudasir A.,
Bhat Gulzar A.,
Idris Ahmed,
Dar Javid A.,
Yousef Al Omar Suliman,
Masoodi Khalid Z.,
Ganai Bashir A.,
Kamili Azra N.,
Shawl Abdul S.
Publication year - 2014
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201400001
Subject(s) - rosmarinic acid , chemistry , antimicrobial , terpene , melissa officinalis , antioxidant , caffeic acid , traditional medicine , stereochemistry , organic chemistry , medicine
Abstract The hydroalcoholic (EtOH/H 2 O) extract of matured leaf margins of lemon balm ( Melissa officinalis L.) afforded a new 3,23‐disulfate of 2 α ,3 β ‐23,29‐tetrahydroxyolean‐12‐en‐28‐oic acid 28‐ O ‐ β ‐ D ‐glucopyranoside ( 1 ) and a new 23‐monosulfate of 2 α ,23‐dihydroxyurs‐12‐en‐28‐oic acid 3‐ O ‐ β ‐ D ‐glucopyranoside ( 2 ), along with six known compounds, i.e. , 23‐monosulfate of 2 α ,3 β ,19 α ,23‐tetrahydroxyurs‐12‐ene‐28‐oic acid 28‐ O ‐ β ‐ D ‐glucopyranoside ( 3 ), 3,5,6‐trihydroxydehydro‐ α ‐ionol 9‐ O ‐ β ‐ D ‐glucopyranoside ( 4 ), quadranoside III ( 5 ), rosmarinic acid ( 6 ), caffeic acid ( 7 ), and luteolin ( 8 ). All the isolated compounds were evaluated for their antioxidant, antimicrobial, antimalarial, and cytotoxic activities. Only rosmarinic acid exhibited substantial antioxidant and antimicrobial activities, whereas sulfated terpenes showed considerably lower or no antimicrobial activity.