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Palmarumycins from the Endophytic Fungus Lasiodiplodia pseudotheobromae XSZ‐3
Author(s) -
Lü Xiaojing,
Chen Gang,
Li Zhanlin,
Zhang Yuhong,
Wang Zaiying,
Rong Weiwei,
Pei Yuehu,
Pan Huaqi,
Hua Huiming,
Bai Jiao
Publication year - 2014
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201300436
Subject(s) - chemistry , circular dichroism , time dependent density functional theory , trypan blue , fungus , absolute configuration , cytotoxic t cell , stereochemistry , density functional theory , botany , computational chemistry , biochemistry , cell , biology , in vitro
One new and three known spiro‐dioxynaphthalene compounds, related to palmarumycins, were isolated from the extracts of fungus Lasiodiplodia pseudotheobromae XSZ‐3. Their structures were established by spectroscopic methods (1D‐ and 2D‐NMR, HR‐ESI‐MS, etc. ). The absolute configuration of 1 was determined by comparison of quantum‐chemical TDDFT (time‐dependent density‐functional theory) calculated and experimental ECD (electronic circular dichroism) spectra. The cytotoxic activities of 1 – 4 against HL‐60 cell line were evaluated by trypan blue‐staining assay.