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Labdane Diterpenoids from the Roots of Amomum maximum and Their Cytotoxic Evaluation
Author(s) -
Luo JianGuang,
Yin Hong,
Fan BoYi,
Kong LingYi
Publication year - 2014
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201300426
Subject(s) - labdane , diterpene , chemistry , stereochemistry , cytotoxic t cell , traditional medicine , in vitro , biochemistry , medicine
A rare labdane diterpene γ ‐lactam, 1 , and two new labdane diterpenoids, 2 and 3 , along with two known diterpenes, 4 and 5 , were isolated from the roots of Amomum maximum. Their structures were established on the basis of spectroscopic data. All of the isolates were evaluated for their cytotoxic activities, and compound 3 was found to exhibit an inhibitory activity against MG‐63 cell lines with an IC 50 value of 3.3±0.8 μg/ml.
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