Premium
Amine‐Promoted One‐Pot, Multicomponent Route to Spiro‐Fused‐Pyran Derivatives in Aqueous Media
Author(s) -
Alizadeh Abdolali,
Rezvanian Atieh,
Bayat Fahimeh
Publication year - 2014
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201300387
Subject(s) - chemistry , malononitrile , ninhydrin , pyran , amine gas treating , aqueous solution , aqueous medium , spectroscopy , extraction (chemistry) , nuclear magnetic resonance spectroscopy , organic chemistry , combinatorial chemistry , catalysis , amino acid , biochemistry , physics , quantum mechanics
The primary amine‐promoted synthesis of spiro‐fused‐pyran derivatives via the three‐component reaction of ninhydrin, malononitrile, and cyclic 1,3‐diketo compounds is described. This new methodology affords the title compounds in high yields and short time, and with easy workup without chromatographic purification steps or extraction. All structures were confirmed by IR, 1 H‐ and 13 C‐NMR spectroscopy, and mass spectroscopy. A plausible mechanism for this type of reaction is proposed ( Scheme 2 ).