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Formal Synthesis of (−)‐Cyclaradine Using Ring Closing Metathesis
Author(s) -
Raju Gurrapu,
Rao Jalagam Prasada,
Rao Batchu Venkateswara
Publication year - 2014
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201300325
Subject(s) - chemistry , ring closing metathesis , formal synthesis , metathesis , stereoselectivity , reagent , ring (chemistry) , combinatorial chemistry , closing (real estate) , grignard reaction , stereochemistry , organic chemistry , catalysis , political science , law , polymerization , polymer
The stereoselective formal synthesis of (−)‐cyclaradine from the inexpensively available starting material L ‐glutamic acid is described, using Eschenmoser 's reagent, and applying Luche reduction, Grignard reaction, and ring closing metathesis (RCM) as the key steps.