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Hypervalent Iodine Catalyzed Cyclization of Aryl‐Substituted Alkanoic Acids
Author(s) -
Li Tingting,
Xiang Changbin,
Zhang Bijun,
Yan Jie
Publication year - 2014
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201300311
Subject(s) - hypervalent molecule , chemistry , iodobenzene , aryl , iodine , catalysis , organic chemistry , medicinal chemistry , combinatorial chemistry , alkyl
A novel and efficient procedure was developed for direct preparation of aryl‐substituted lactones from corresponding aryl‐substituted alkanoic acids, catalyzed by the in situ generated hypervalent iodine intermediate from iodobenzene (PhI). In this protocol, aryl‐substituted alkanoic acids were treated with m‐ chloroperbenzoic acid ( m CPBA) and KBr in the presence of a catalytic amount of PhI in 2,2,2‐trifluoroethanol at room temperature for 24 h, resulting in corresponding aryl lactones in moderate‐to‐good yields.