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Catalytic Performance of Polystyrene‐Bound ChibaG Derivatives as Guanidine Organobases in Asymmetric Michael Additions
Author(s) -
Ishikawa Tsutomu,
Heima Takashi,
Yoshida Makoto,
Kumamoto Takuya
Publication year - 2014
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201300259
Subject(s) - chemistry , guanidine , polystyrene , substituent , catalysis , methyl vinyl ketone , michael reaction , ketone , ether , organic chemistry , medicinal chemistry , polymer chemistry , polymer
The guanidine organocatalyst, ChibaG , was bound via an ether linkage to the phenyl group of the 2‐imino substituent to Merrifield resin. Polystyrene‐bound ChibaG acted as an effective catalyst in the Michael reaction of tert ‐butyl N ‐(diphenylmethylidene)glycinate with methyl vinyl ketone, and could be recovered and reused many times.