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A Stereoselective Total Synthesis of Decarestrictine I
Author(s) -
Yadav Jhillu Singh,
Venkatesh Miriyal,
Kumar Alleni Suman,
Reddy Poli Adi Narayana,
Reddy Basi V. Subba,
Prasad Attaluri R.
Publication year - 2014
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201300256
Subject(s) - chemistry , stereoselectivity , total synthesis , metathesis , polyketide , malic acid , alcohol , ring closing metathesis , natural product , stereochemistry , sharpless epoxidation , convergent synthesis , organic chemistry , biosynthesis , catalysis , polymer , citric acid , polymerization , enzyme
A convergent and stereoselective total synthesis of decarestrictine I, a polyketide natural product, is described. Both acid and alcohol fragments were prepared from the readily available L ‐malic acid via StillGennari olefination and Sharpless asymmetric epoxidation. The Steglich esterification and ring‐closing metathesis (RCM) are employed to combine both acid and alcohol fragments.