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Biotransformation of Oleaside A by Cunninghamella echinulata
Author(s) -
Lu Min,
Liu QingXin,
Han ZhuZhen,
Hu XianQing,
Zhang WeiDong,
Wan Ping,
Li HuiLiang
Publication year - 2014
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201300180
Subject(s) - chemistry , biotransformation , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , cancer cell lines , organic chemistry , cancer , cancer cell , enzyme , medicine
Biotransformation of oleaside A ( 1 ) by Cunninghamella echinulata (ACCC 30369) was carried out to afford two products, (6 R )‐6‐hydroxyoleaside A ( 2 ) and (7 S )‐7‐hydroxyoleaside A ( 3 ). The structures of 2 and 3 were elucidated by extensive NMR analyses and further confirmed by single‐crystal X‐ray diffraction analysis. We also report herein the X‐ray diffraction structure of oleaside A ( 1 ) for the first time. Compounds 1 – 3 were evaluated for their cytotoxic activities against the A549, HCT116, HepG2, and HL‐60 human cancer cell lines.