Premium
Biotransformation of Oleaside A by Cunninghamella echinulata
Author(s) -
Lu Min,
Liu QingXin,
Han ZhuZhen,
Hu XianQing,
Zhang WeiDong,
Wan Ping,
Li HuiLiang
Publication year - 2014
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201300180
Subject(s) - chemistry , biotransformation , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , cancer cell lines , organic chemistry , cancer , cancer cell , enzyme , medicine
Biotransformation of oleaside A ( 1 ) by Cunninghamella echinulata (ACCC 30369) was carried out to afford two products, (6 R )‐6‐hydroxyoleaside A ( 2 ) and (7 S )‐7‐hydroxyoleaside A ( 3 ). The structures of 2 and 3 were elucidated by extensive NMR analyses and further confirmed by single‐crystal X‐ray diffraction analysis. We also report herein the X‐ray diffraction structure of oleaside A ( 1 ) for the first time. Compounds 1 – 3 were evaluated for their cytotoxic activities against the A549, HCT116, HepG2, and HL‐60 human cancer cell lines.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom