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Alkaloids from Ochrosia borbonica
Author(s) -
Zhang BingJie,
Yan JuMing,
Wu ZiKun,
Liu YaPing,
Bao MeiFen,
Cheng GuiGuang,
Luo XiaoDong,
Cai XiangHai,
Li Yan
Publication year - 2013
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201300136
Subject(s) - chemistry , stereochemistry , cancer cell lines , indole test , glucoside , two dimensional nuclear magnetic resonance spectroscopy , cytotoxic t cell , cytotoxicity , cancer cell , biochemistry , cancer , in vitro , medicine , alternative medicine , pathology
Ten new monoterpenoid indole alkaloids, ochroborines A and B ( 1 and 2 , resp.), 10‐hydroxyisovallesiachotamine ( 3 ), 10‐hydroxyisositsirikine ( 4 ), 10,11‐dimethoxysitsirikine ( 5 ), 10‐methoxyapoyohimbine ( 6 ), 10‐hydroxyakuammidine ( 7 ), akuammidine 17‐ O ‐ β ‐ D ‐glucoside ( 8 ), 15 α ‐hydroxyapparicine ( 9 ), and 15 α ‐hydroxy‐10‐methoxyapparicine ( 10 ), and 24 known alkaloids were isolated from leaves and twigs of Ochrosia borbonica J. F. Gmel . These structures were elucidated based on 1D‐ and 2D‐NMR, FT‐IR, UV, and MS data. 10‐Hydroxyisovallesiachotamine ( 3 ), ellipticine, and 10‐methoxyellipticine showed cytotoxic activities against five human cancer cell lines.
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