Premium
Coumarinolignans Isolated from the Seeds of Brucea javanica
Author(s) -
Yang Jianhong,
Liu Wenyu,
Li Shucai,
Ye Haoyu,
Tang Huan,
Chen Lijuan,
Peng Aihua
Publication year - 2014
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201300127
Subject(s) - chemistry , nitric oxide , lipopolysaccharide , stereochemistry , traditional medicine , organic chemistry , medicine , endocrinology
A new coumarinolignan, cleomiscosin E ( 1 ), together with the known compound cleomiscosin A ( 2 ), has been isolated from the seeds of Brucea javanica (L.) Merr . Their structures were assigned on the basis of spectral studies. These two compounds exhibited potent anti‐inflammatory activities by inhibiting the nitric oxide (NO) production in lipopolysaccharide (LPS)‐activated RAW264.7 macrophages.