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Two New Cytotoxic Spirostane‐Steroidal Saponins from the Roots of Bletilla striata
Author(s) -
Park Jong Eel,
Woo Kyeong Wan,
Choi Sang Un,
Lee Je Hyun,
Lee Kang Ro
Publication year - 2014
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201300102
Subject(s) - chemistry , cytotoxicity , in vitro , stereochemistry , cytotoxic t cell , bioassay , two dimensional nuclear magnetic resonance spectroscopy , tumor cells , traditional medicine , biochemistry , genetics , cancer research , biology , medicine
Two new spirostane‐steroidal saponins, bletilnoside A ( 1 ) and bletilnoside B ( 2 ), together with five known compounds, 3 – 7 , were isolated from the roots of Bletilla striata ( Thunb .) Reichb . F. The structures of the new compounds were determined based on their 1D‐ and 2D‐NMR spectral data. The isolated compounds 1 – 7 were tested for cytotoxicity against four human tumor cells (A549, SK‐OV‐3, SK‐MEL‐2, and HCT15) in vitro using a sulforhodamin B bioassay, and compounds 1, 2 , and 5 showed significant cytotoxicities against all tested tumor cell lines with IC 50 values ranging from 3.98±0.16 to 12.10±0.40 μ M .