Metal‐Ion‐Binding Analogs of Ribonucleosides: Preparation and Formation of Ternary Pd 2+  and Hg 2+  Complexes with Natural Pyrimidine Nucleosides | Zendy

Golubev Oleg | Zendy; Lönnberg Tuomas | Zendy; Lönnberg Harri | Zendy

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Metal‐Ion‐Binding Analogs of Ribonucleosides: Preparation and Formation of Ternary Pd 2+ and Hg 2+ Complexes with Natural Pyrimidine Nucleosides

Author(s) -

Golubev Oleg,

Lönnberg Tuomas,

Lönnberg Harri

Publication year - 2013

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.201300042

Subject(s) - chemistry , pyrimidine , ternary operation , metal , purine , pyridine , uridine , ribonucleoside , nuclear magnetic resonance spectroscopy , derivative (finance) , medicinal chemistry , ternary complex , stereochemistry , metal ions in aqueous solution , organic chemistry , enzyme , rna , biochemistry , computer science , financial economics , economics , gene , programming language

Four metal‐ion‐binding nucleosides, viz. 2,6‐bis(1‐methylhydrazinyl)‐9‐( β ‐ D ‐ribofuranosyl)‐9 H ‐purine ( 2a ) and its N ‐acetylated derivative, 2b , 2,4‐bis(3,5‐dimethyl ‐ 1 H ‐pyrazol‐1‐yl)‐5‐( β ‐ D ‐ribofuranosyl)pyrimidine ( 3 ), and 2,4‐bis(1‐methylhydrazinyl)‐5‐( β ‐ D ‐ribofuranosyl)pyrimidine ( 4 ) have been synthesized. The ability of these nucleosides and the previously prepared 2,6‐bis(3,5‐dimethyl ‐ 1 H ‐pyrazol‐1‐yl)‐9‐( β ‐ D ‐ribofuranosyl)‐9 H ‐purine to form Pd 2+ ‐ and Hg 2+ ‐mediated complexes with uridine has been studied by 1 H‐NMR spectroscopy. To obtain additional support for the interpretation of the NMR data, comparative measurements on the ternary‐complex formation between pyridine‐2,6‐dicarboxamide ( 5 ), pyrimidine nucleosides, and K 2 PdCl 4 were carried out.

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