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Concise Stereoselective Total Synthesis of Leiocarpin C
Author(s) -
Chandra Rao Dasireddi,
Shekhar Vanam,
Kumar Reddy Dorigondla,
Chinnababu Baggu,
Venkateswarlu Yenamandra
Publication year - 2013
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200656
Subject(s) - chemistry , stereoselectivity , total synthesis , hydroxylation , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , enzyme
A simple and highly concise strategy has been developed for the stereoselective total synthesis of leiocarpin C starting from commercially available mandelic ester. The strategy utilizes the OsO 4 ‐catalyzed cis ‐hydroxylation and selective reduction with K‐Selectride as key steps.
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