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Two New Naphthoquinone Derivatives from Lysionotus pauciflorus
Author(s) -
Zhong YuJiao,
Wen QingFa,
Li CongYing,
Su XueHui,
Yuan ZhiPeng,
Li YanFang
Publication year - 2013
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200627
Subject(s) - chemistry , naphthoquinone , stereochemistry , cytotoxic t cell , tumor cells , in vitro , organic chemistry , biochemistry , cancer research , biology
Two new naphthoquinones, (2 R )‐6,8‐dihydroxy‐ α ‐dunnione ( 1 ), 6,8‐dihydroxy‐2,7‐dimethoxy‐3‐(1,1‐dimethylprop‐2‐enyl)‐1,4‐naphthoquinone ( 2 ), together with three known compounds, (2 R )‐6,8‐dihydroxy‐7‐methoxy‐ α ‐dunnione ( 3 ), nevadensin ( 4 ), and lysioside C ( 5 ), were isolated from the whole plant of Lysionotus pauciflorus. Their structures were established by spectroscopic methods. Hydroxylated naphthoquinones are reported to occur in a Lysionotus species for the first time. The cytotoxic activities of compounds 1 – 3 were evaluated in vitro against a panel of tumor cell lines.