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Electrochemical Phenylselenoetherification as a Key Step in the Synthesis of (±)‐Curcumene Ether
Author(s) -
Stevanović Dragana,
Pejović Anka,
Damljanović Ivan S.,
Vukićević Mirjana D.,
Dobrikov Georgi,
Dimitrov Vladimir,
Denić Marija S.,
Radulović Niko S.,
Vukićević Rastko D.
Publication year - 2013
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200610
Subject(s) - chemistry , ether , intramolecular force , electrochemistry , key (lock) , combinatorial chemistry , stereochemistry , organic chemistry , electrode , ecology , biology
Two variants of a new pathway for the synthesis of (±)‐curcumene ether are described. The key steps in these procedures are intramolecular cyclizations of 6‐methyl‐2‐(4‐methylphenyl)hept‐6‐en‐2‐ol and 2‐methyl‐6‐(4‐methylphenyl)hept‐6‐en‐2‐ol by means of an electrochemically generated phenylselenyl cation. This synthetic approach provides significantly better yields than the previously reported protocols.