A Transformation of  N ‐Alkylated Anilines to  N ‐Aryloxamates | Zendy

Zhu XiaoHe | Zendy; Zhang Xin | Zendy; Xin HongXing | Zendy; Yan Hong | Zendy

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A Transformation of N ‐Alkylated Anilines to N ‐Aryloxamates

Author(s) -

Zhu XiaoHe,

Zhang Xin,

Xin HongXing,

Yan Hong

Publication year - 2013

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.201200603

Subject(s) - chemistry , alkylation , catalysis , transformation (genetics) , medicinal chemistry , aniline , reaction conditions , organic chemistry , biochemistry , gene

Transformation of N ‐alkylated anilines to N ‐aryloxamates was studied using ethyl 2‐diazoacetoacetate as an alkylating agent and dirhodium tetraacetate (Rh 2 (OAc) 4 ) as the catalyst. The general applicability of the reaction as a synthetic method for N ‐aryloxamates was studied with a number of substituted N ‐alkylated anilines. The results revealed that the oxamate was formed by a radical reaction with molecular O 2 and Rh 2 (OAc) 4 as initiator.

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