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A Transformation of N ‐Alkylated Anilines to N ‐Aryloxamates
Author(s) -
Zhu XiaoHe,
Zhang Xin,
Xin HongXing,
Yan Hong
Publication year - 2013
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200603
Subject(s) - chemistry , alkylation , catalysis , transformation (genetics) , medicinal chemistry , aniline , reaction conditions , organic chemistry , biochemistry , gene
Transformation of N ‐alkylated anilines to N ‐aryloxamates was studied using ethyl 2‐diazoacetoacetate as an alkylating agent and dirhodium tetraacetate (Rh 2 (OAc) 4 ) as the catalyst. The general applicability of the reaction as a synthetic method for N ‐aryloxamates was studied with a number of substituted N ‐alkylated anilines. The results revealed that the oxamate was formed by a radical reaction with molecular O 2 and Rh 2 (OAc) 4 as initiator.