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Copper‐Catalyzed Synthesis of 2 H ‐Thiopyran Derivatives from Alkynes, Sulfonyl Azides, Carbon Disulfide, and Malononitrile
Author(s) -
Yavari Issa,
Nematpour Manijeh,
Tavakoli Ziba
Publication year - 2013
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200600
Subject(s) - malononitrile , chemistry , thiopyran , sulfonyl , catalysis , carbon disulfide , disulfide bond , medicinal chemistry , organic chemistry , combinatorial chemistry , biochemistry , alkyl
A one‐pot synthesis of functionalized thiopyran derivatives via a Cu‐catalyzed multicomponent reaction of sulfonyl azides, arylacetylenes and dipotassium 2,2‐dicyanoethylene‐1,1‐dithiolate, generated from malononitrile and CS 2 , has been developed. When alkylacetylenes were used as the terminal alkynes, N ‐(alkanethioyl)‐ N ‐(2,2‐dicyanoethanethioyl)methanesulfonamides were obtained in good yields.