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Juglanones A and B: Two Novel Tetralone Dimers from Walnut Pericarp ( Juglans regia )
Author(s) -
Li CongYing,
Du HongJian,
Su XueHui,
Zhong YuJiao,
Yuan ZhiPeng,
Li YanFang,
Liang Bing
Publication year - 2013
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200525
Subject(s) - chemistry , juglans , tetralones , tetralone , two dimensional nuclear magnetic resonance spectroscopy , stereochemistry , biochemistry
Two novel tetralone dimers, with an O‐bridge, named juglanones A and B ( 1 and 2 , resp.), were isolated from the AcOEt extract of walnut pericarps. These compounds are the first examples of O‐bridged dimeric tetralones. Their structures were determined by spectroscopic methods, including HR‐TOF‐MS, and 1D‐ and 2D‐NMR. Biological evaluation of these two isolates against a number of human cancer cell lines is also described.