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Synthesis of Monospiro‐2‐amino‐4 H ‐pyran Derivatives Catalyzed by Propane‐1‐sulfonic Acid‐Modified Magnetic Hydroxyapatite Nanoparticles
Author(s) -
JaliliBaleh Leili,
Mohammadi Narges,
Khoobi Mehdi,
Ma'mani Leila,
Foroumadi Alireza,
Shafiee Abbas
Publication year - 2013
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200516
Subject(s) - chemistry , malononitrile , pyran , ninhydrin , catalysis , sulfonic acid , propane , nanoparticle , magnetic nanoparticles , organic chemistry , solvent , nuclear chemistry , amino acid , chemical engineering , biochemistry , engineering
Various monospiro‐2‐amino‐4 H ‐pyran derivatives have been synthesized in high yields ( via three‐component coupling of ninhydrin or different isatins with malononitrile and 1,3‐dicarbonyl compounds) in the presence of catalytic amount of propane‐1‐sulfonic acid‐modified magnetic hydroxyapatite nanoparticles in H 2 O. Due to easy magnetic removal of nanocatalyst and applying of H 2 O as solvent, this protocol enhanced product purity, and promised economic as well as environmental benefits, exemplifying a waste‐free chemistry. More importantly, the catalyst could be easily recycled for more than five times without loss of activity.