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2‐Amino‐1,2,3,6‐tetrahydro‐6‐oxocyclopenta[ c ]fluorene‐2‐carboxylic Acid (FlAib), a Completely Rigidified, Fluoren‐9‐one‐Based α ‐Amino Acid
Author(s) -
Wright Karen,
Alvarez Antonio Blanco,
Crisma Marco,
Toffoletti Antonio,
Formaggio Fernando,
Toniolo Claudio
Publication year - 2012
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200490
Subject(s) - chemistry , fluorene , carboxylic acid , glycine , amino acid , stereochemistry , absolute configuration , resolution (logic) , organic chemistry , polymer , biochemistry , artificial intelligence , computer science
The synthesis, optical resolution, determination of absolute configuration and conformational preference, and spectroscopic characteristics of terminally protected (blocked) derivatives and short peptides of 2‐amino‐1,2,3,6‐tetrahydro‐6‐oxocyclopenta[ c ]fluorene‐2‐carboxylic acid (FlAib), a novel, rigid, chiral, cyclized C α , α ‐disubstituted glycine are described.