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Organic Stereochemistry. Part 3
Author(s) -
Testa Bernard
Publication year - 2013
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200471
Subject(s) - stereocenter , chemistry , chirality (physics) , stereochemistry , axial chirality , isomerization , helicity , enantioselective synthesis , organic chemistry , catalysis , chiral symmetry breaking , physics , particle physics , quantum mechanics , quark , nambu–jona lasinio model
This review continues a general presentation of the principles of stereochemistry with special reference to medicinal compounds. Here, we discuss further stereogenic elements other than the stereogenic centers presented in Part 2. These are the axis of chirality, the plane of chirality, helicity, and ( E , Z ) ‐ diastereoisomerism (stereoisomerism about double bonds). Some of these elements of stereoisomerism are not always well understood, and they raise specific convention issues. Isomerization reactions will also be discussed. As far as possible, the examples we present have biochemical and mainly medicinal relevance; a systematic overview concerning biosystems will be presented in Parts 5–8.