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Microwave‐Assisted Synthesis of β ‐Lactams and Cyclo‐ β ‐dipeptides
Author(s) -
HernándezVázquez Luis G.,
Leyva Marco A.,
MettaMagaña Alejandro J.,
Escalante Jaime
Publication year - 2012
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200449
Subject(s) - chemistry , dipeptide , lactam , substituent , stereochemistry , diketopiperazines , crystal structure , benzene , alanine , amino acid , combinatorial chemistry , organic chemistry , biochemistry
Different cyclo‐ β ‐dipeptides were prepared from corresponding N ‐substituted β ‐alanine derivatives under mild conditions using PhPOCl 2 as activating agent in benzene and Et 3 N as base. To evaluate β 3 ‐substituent influence, the amino acids 7 – 26 were synthesized, and a β ‐lactam formation reaction was carried out instead of cyclo‐ β ‐dipeptide formation. The crystal structures of three derivatives of cyclo‐ β ‐peptides and one β ‐lactam are presented.