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A Manifold Three‐Step Synthetic Route to Polycyclic Annulated Hydantoins via Cyclic Imines
Author(s) -
Brockmeyer Fabian,
Kröger Denis,
Stalling Timo,
Ullrich Pasqual,
Martens Jürgen
Publication year - 2012
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200441
Subject(s) - chemistry , combinatorial chemistry , ring (chemistry) , reaction conditions , stereochemistry , computational chemistry , organic chemistry , catalysis
A new three‐step synthetic pathway to generate polycyclic annulated hydantoins via rarely investigated heterocyclic imines is described. This procedure includes a one‐pot reaction forming imines as precursor structures ( e.g., Asinger reaction), followed by an Ugi reaction to build up a bisamide structure that allows a ring‐closing reaction to the targeted hydantoins via substitution. This pathway leads to a multiplicity of substances with a potential pharmacological activity.