A Manifold Three‐Step Synthetic Route to Polycyclic Annulated Hydantoins  via  Cyclic Imines | Zendy

Brockmeyer Fabian | Zendy; Kröger Denis | Zendy; Stalling Timo | Zendy; Ullrich Pasqual | Zendy; Martens Jürgen | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

A Manifold Three‐Step Synthetic Route to Polycyclic Annulated Hydantoins via Cyclic Imines

Author(s) -

Brockmeyer Fabian,

Kröger Denis,

Stalling Timo,

Ullrich Pasqual,

Martens Jürgen

Publication year - 2012

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.201200441

Subject(s) - chemistry , combinatorial chemistry , ring (chemistry) , reaction conditions , stereochemistry , computational chemistry , organic chemistry , catalysis

A new three‐step synthetic pathway to generate polycyclic annulated hydantoins via rarely investigated heterocyclic imines is described. This procedure includes a one‐pot reaction forming imines as precursor structures ( e.g., Asinger reaction), followed by an Ugi reaction to build up a bisamide structure that allows a ring‐closing reaction to the targeted hydantoins via substitution. This pathway leads to a multiplicity of substances with a potential pharmacological activity.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research