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A Total Synthesis of Aliskiren
Author(s) -
Nam Gyeok,
Ko Soo Y.
Publication year - 2012
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200425
Subject(s) - chemistry , aliskiren , total synthesis , combinatorial chemistry , stereochemistry , medicine , renin–angiotensin system , blood pressure
A total synthesis of aliskiren ( 20 ) was accomplished. A key in our synthesis was to use the symmetric trans‐cisoid‐trans‐ bis‐lactone 1 as a precursor. It was expediently prepared by three different routes ( Scheme 2 ). Appending the end groups and functional group transformations completed the synthesis ( Scheme 3 ).
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