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Five New Nortriterpenoids from the Stems of Schisandra neglecta
Author(s) -
Liang ChengQin,
Hu Jing,
Shi YiMing,
Shang ShanZhai,
Du Xue,
Zhan Rui,
Wang WeiGuang,
Xiong WenYong,
Xiao WeiLie,
Zhang HongBin,
Sun HanDong
Publication year - 2013
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200392
Subject(s) - chemistry , schisandra , schisandra chinensis , insulin sensitivity , stereochemistry , traditional medicine , insulin , insulin resistance , medicine , alternative medicine , pathology , traditional chinese medicine
Five new nortriterpenoids, schicagenins D–F ( 1 – 3 , resp.) and negleschidilactones A and B ( 4 and 5 , resp.), together with eleven known ones, were isolated from the stems of Schisandra neglecta. Their structures were established on the basis of extensive spectroscopic analyses. All the compounds were evaluated for their activities regarding insulin sensitivity in 3T3‐L1 differentiated adipocytes. None of them showed a significant bioactivity at 10 μ M concentration.