Premium
N ‐Iodosuccinimide: A Highly Effective Regioselective Reagent for Iodoesterification of Alkenes
Author(s) -
Reddy Aleti R.,
Sangwan Payare L.,
Chinthakindi Praveen K.,
Farooq Saleem,
Siddaiah Vidavalur,
Koul Surrinder
Publication year - 2013
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200383
Subject(s) - chemistry , regioselectivity , reagent , combinatorial chemistry , organic chemistry , amino acid , catalysis , biochemistry
A rapid, convenient, and efficient method has been achieved for regioselective iodoesterification of alkenes with aliphatic and aromatic acids, and protected amino acids in the presence of N ‐iodosuccinimide (NIS) in nearly quantitative yields. Optically enriched iodohydrins have been achieved by LiAlH 4 (LAH) reduction of diastereoisomeric iodo esters.