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New Cytotoxic Triterpenoids from the Aerial Parts of Euphorbia sieboldiana
Author(s) -
Zhang BeiBei,
Jiang Qian,
Liao ZhiXin,
Liu Chao,
Liu ShiJun
Publication year - 2013
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200377
Subject(s) - chemistry , triterpenoid , phytochemical , hela , oleanane , stereochemistry , terpene , cytotoxic t cell , euphorbia , euphorbiaceae , traditional medicine , botany , triterpene , biochemistry , cell , in vitro , biology , pathology , medicine , alternative medicine
Abstract Phytochemical investigation of the EtOH extract of Euphorbia sieboldiana led to the isolation of four new oleanane‐type triterpenoids, (1 β ,2 α ,3 β ,19 β )‐1,2,3,19‐tetrahydroxyolean‐12‐en‐28‐oic acid, (1 β ,3 β ,19 β )‐1,3,19‐trihydroxyolean‐12‐en‐28‐oic acid, (1 β ,2 α ,3 β ,16 β ,19 β )‐1,2,3,16,19‐pentahydroxyolean‐12‐en‐28‐oic acid, and (1 β ,2 α ,3 β ,19 β ,23)‐1,2,3,19,23‐pentahydroxyolean‐12‐en‐28‐oic acid, along with 16 known compounds. Their structures were established by extensive 1D‐ and 2D‐NMR, as well as other spectral analyses. Biological evaluation of the four new triterpenoids revealed potent cytotoxic activities against HeLa and Hep‐G2 cells.