Premium
Stereoselective Total Synthesis of Passifloricin A
Author(s) -
Reddy Cheruku Ravindra,
Veeranjaneyulu Boyapati,
Nagendra Siddavatam,
Das Biswanath
Publication year - 2013
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200356
Subject(s) - chemistry , stereoselectivity , total synthesis , olefin metathesis , metathesis , stereochemistry , olefin fiber , antiprotozoal , salt metathesis reaction , carbonate , combinatorial chemistry , organic chemistry , catalysis , biochemistry , polymer , in vitro , polymerization
The stereoselective total synthesis of passifloricin A ( 1 ), a naturally occurring dihydropyranone with leishmanicidal and antiprotozoal activities, has been accomplished starting from protected glyceraldehyde using Maruoka asymmetric allylation, diastereoselective iodo‐carbonate cyclization, and Grubbs ' olefin metathesis reactions as the key steps.