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A Fused Benzocyclooctene Ring System via an Aromatic Cope Rearrangement: Thermal Reactions of trans ‐1‐Aryl‐2‐ethenylcyclobutanecarbonitriles
Author(s) -
ÁvilaZárraga José Gustavo,
VázquezSánchez Adrián,
Maldonado Luis Ángel
Publication year - 2013
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200352
Subject(s) - chemistry , aryl , ring (chemistry) , cope rearrangement , transformation (genetics) , smiles rearrangement , stereochemistry , medicinal chemistry , organic chemistry , biochemistry , alkyl , gene
The results of an aromatic Cope rearrangement of a trans ‐1‐aryl‐2‐ethenylcyclobutanecarbonitrile are reported ( Scheme ). The use of this rearrangement for the construction of the fused benzocyclooctene ring system and a preliminary study of the electronic requirements to favor such a transformation are also described.