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Biotransformation of Jervine by Cunninghamella echinulata
Author(s) -
Chen KeYu,
Lü YiFeng,
Zhang WeiDong,
Tang Jian,
Liu RunHui,
Li HuiLiang
Publication year - 2013
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200345
Subject(s) - biotransformation , chemistry , stereochemistry , organic chemistry , enzyme
Biotransformation of jervine ( 1 ) by Cunninghamella echinulata (ACCC 30369) was carried out. Four biotransformation products were obtained, and three of them, 3 – 5 , were identified as new compounds. On the basis of their NMR and mass‐spectral data, their structures were characterized as jervinone ( 2 ), 7 α ‐hydroxyjervine ( 3 ), 14 α ‐hydroxyjervine ( 4 ), and 1 β ,7 α ‐dihydroxyjervine ( 5 ). The X‐ray diffraction structure of 1 is also reported for the first time.