Enantioselective Synthesis of (−)‐( R )‐Cordiachromene and (−)‐( R )‐Dictyochromenol Utilizing Intramolecular  S  N Ar Reaction | Zendy

Noda Yoshihiro | Zendy; Yasuda Misato | Zendy

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Enantioselective Synthesis of (−)‐( R )‐Cordiachromene and (−)‐( R )‐Dictyochromenol Utilizing Intramolecular S N Ar Reaction

Author(s) -

Noda Yoshihiro,

Yasuda Misato

Publication year - 2012

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.201200312

Subject(s) - enantioselective synthesis , chemistry , intramolecular force , chirality (physics) , stereochemistry , ring (chemistry) , catalysis , combinatorial chemistry , organic chemistry , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , quark

A simple and efficient enantioselective synthesis of chromene, (−)‐( R )‐cordiachromene ( 1 ), and (−)‐( R )‐dictyochromenol ( 2 ) has been accomplished. This convergent synthesis utilizes intramolecular S N Ar reaction for the formation of chroman ring, and Seebach 's method of ‘ self‐reproduction of chirality ’ should establish the ( R )‐configuration of the C(2) side chain as key steps.

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