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Natural (−)‐Vasicine as a Novel Source of Optically Pure 1‐Benzylpyrrolidin‐3‐ol
Author(s) -
Aga Mushtaq A.,
Kumar Brijesh,
Rouf Abdul,
Shah Bhahwal A.,
Andotra Samar S.,
Taneja Subhash C.
Publication year - 2013
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200307
Subject(s) - chemistry , alkaloid , optically active , yield (engineering) , combinatorial chemistry , organic chemistry , stereochemistry , metallurgy , materials science
A facile and scalable methodology for the preparation of optically active (3 S )‐1‐benzylpyrrolidin‐3‐ol ( 3 ), an important drug precursor, is reported. Starting from the naturally occurring alkaloid (−)‐vasicine ( 1 ), a major alkaloid of the plant Adhatoda vasica , 3 was obtained in 84% overall yield ( Scheme 3 ).
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