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Synthesis of Natural Atisane‐Type Diterpenoids by retro ‐Biomimetic Transformations
Author(s) -
Ungur Nicon,
Kulciţki Veaceslav,
Chetraru Olga,
Grinco Marina,
Vlad Pavel F.
Publication year - 2013
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200305
Subject(s) - chemistry , sunflower , biomimetic synthesis , stereochemistry , natural (archaeology) , organic chemistry , natural compound , terpene , type (biology) , combinatorial chemistry , biochemical engineering , ecology , archaeology , biology , history , mathematics , combinatorics , engineering
An efficient one step, retro ‐biomimetic procedure for the synthesis of natural products having the atisane structure is described ( Scheme 2 ), natural products which are components of medicinal plants and possess relevant biological activity. Their structures were confirmed by chemical transformations and spectral data. The starting materials were the known ent ‐kaur‐16‐en‐19‐oic acid ( 1 ) and ent ‐trachyloban‐19‐oic acid ( 2 ), diterpenoids readily available from the waste of sunflower.