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Isoindolones from Lasiosphaera fenzlii Reich . and Their Bioactivities
Author(s) -
Lü WenWen,
Gao YunJia,
Su MingZhi,
Luo Zhou,
Zhang Wei,
Shi GuoBing,
Zhao QingChun
Publication year - 2013
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200279
Subject(s) - chemistry , secretion , vascular endothelial growth factor , vegf receptors , stereochemistry , biochemistry , cancer research , biology
Two new, 1 and 2 , along with one known isoindolone, 3 , were isolated from the AcOEt extract of Lasiosphaera fenzlii Reich . The structures of these compounds were determined as 4,6‐dihydroxy‐1 H ‐isoindole‐1,3(2 H )‐dione ( 1 ), 4,6‐dihydroxy‐2,3‐dihydro‐1 H ‐isoindol‐1‐one ( 2 ), and clitocybin A ( 3 ) on the basis of chemical and spectroscopic evidences. The bioactivity assays revealed that all of them were devoid of significant cytotoxicities against tumor cells, whereas 1 exhibited potent antiangiogenic activity by inhibiting the secretion of vascular endothelial growth factor (VEGF) in A549 cells.