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Cytotoxic Diterpenoids from the Stem Bark of Annona squamosa L.
Author(s) -
Zhou ChangXin,
Sun LiRui,
Feng Feng,
Mo JianXia,
Zhu Hong,
Yang Bo,
He QiaoJun,
Gan LiShe
Publication year - 2013
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200249
Subject(s) - chemistry , annona squamosa , stereochemistry , cytotoxic t cell , annonaceae , bark (sound) , diterpene , traditional medicine , biochemistry , in vitro , biology , medicine , ecology
Three new ent ‐kaurane diterpenoids, (4 α )‐19‐nor‐ ent ‐kaurane‐4,16,17‐triol ( 1 ), (4 α ,16 α )‐17‐(acetyloxy)‐19‐nor‐ ent ‐kaurane‐4,16 ‐ diol ( 2 ), and 17‐hydroxy‐ ent ‐kaur‐15‐en‐19‐al ( 3 ), together with 11 known compounds, were isolated from the stem bark of Annona squamosa L. The structures of 1 – 3 were identified by analysis of their spectroscopic data. All compounds were evaluated for cytotoxic activity against human lung cancer (95‐D) and ovarian cancer (A2780) cell lines, and compounds 3, 5, 7, 11 – 14 exhibited promising antiproliferative activities with IC 50 values ranging from 0.38 to 34.66 μ M .