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Sesterterpenes and 2 H ‐Pyran‐2‐ones (= α ‐Pyrones) from the Mangrove‐Derived Endophytic Fungus Fusarium proliferatum MA‐84
Author(s) -
Liu Dong,
Li XiaoMing,
Li ChunShun,
Wang BinGui
Publication year - 2013
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200195
Subject(s) - artemia salina , brine shrimp , fusarium proliferatum , pyran , chemistry , stereochemistry , fungus , mangrove , botany , food science , biology , organic chemistry , ecology , mycotoxin , toxicity
Two new tricyclic sesterterpenes, fusaprolifins A and B ( 1 and 2 ), and three new 2 H‐ pyran‐2‐one derivatives, prolipyrones A – C ( 3 – 5 ), were isolated and characterized from Fusarium proliferatum MA‐84, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Bruguiera sexangula. In addition, two known sesterterpenes, terpestacin ( 6 ) and fusaproliferin ( 7 ), and one known 2 H ‐pyran‐2‐one derivative, gibepyrone D ( 8 ), were also identified. The structures of these compounds were elucidated by detailed spectroscopic analyses. Fusaprolifin A ( 1 ) showed moderate activity against brine shrimp ( Artemia salina ), with a lethality rate of 49.5% at 100 μg/ml, while fusaprolifin B ( 2 ) showed weak activity.
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