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A Facile Solid‐Phase Synthesis of (+)‐( S )‐Clopidogrel
Author(s) -
Jung Kiwon,
Kim JaeSun,
Kim TaeHyun,
Kim Jinwoong
Publication year - 2013
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200185
Subject(s) - chemistry , clopidogrel , yield (engineering) , solid phase synthesis , phase (matter) , combinatorial chemistry , organic chemistry , thermodynamics , aspirin , peptide , biochemistry , physics
Enantiomerically pure (+)‐( S )‐clopidogrel was prepared by solid‐phase synthesis using the commercially available Wang resin. This method offers mild reaction conditions and provides the (+)‐( S )‐clopidogrel in overall 52% yield over six steps and with optical purity of 98.0% ee.
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