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Rhopeptin A: First Cyclopeptide Isolated from Rhodobryum giganteum
Author(s) -
Jiao Wei,
Wu Zhijun,
Chen Xiaozhen,
Lu Runhua,
Shao Huawu
Publication year - 2013
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200179
Subject(s) - chemistry , pyroglutamic acid , tyrosine , residue (chemistry) , stereochemistry , phenylalanine , proline , side chain , amino acid , amino acid residue , cyclic peptide , peptide , ether , ring (chemistry) , organic chemistry , peptide sequence , biochemistry , gene , polymer
Rhopeptin A was isolated as the first cyclopentapeptide from the moss Rhodobyum giganteum [ Schwaegr.] Par . This novel compound consists of proline, phenylalanine, and 3‐hydroxyproline ring‐bonded amino acid residues connected to a tyrosine fragment via an ether bridge. Attached to a 3‐hydroxyproline unit is a side chain of pyroglutamic acid residue. The structure of the peptide was deduced from the 1D‐ and 2D‐NMR and MS data.