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Two New Abietane Diterpenoids from the Roots of Tripterygium wilfordii Hook . f.
Author(s) -
Li JianYou,
Peng Ying,
Li LingZhi,
Gao PinYi,
Gao Chang,
Xia SuXia,
Song ShaoJiang
Publication year - 2013
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200167
Subject(s) - abietane , tripterygium wilfordii , chemistry , stereochemistry , tripterygium , terpenoid , diterpene , two dimensional nuclear magnetic resonance spectroscopy , medicine , alternative medicine , pathology , glycoside
Two new abietane‐type diterpenoids, named triptobenzene R ( 1 ) and triptobenzene S ( 2 ), together with three known abietane‐type diterpenoids, triptophenolide ( 3 ), triptonodiol ( 4 ), and triptonoterpene methyl ether ( 5 ), were isolated from the roots of Tripterygium wilfordii Hook . f. Their structures and relative configurations were established by detailed spectral studies, including 1D‐ and 2D‐NMR (HSQC, HMBC, and NOESY), and HR‐ESI‐TOF‐MS, and by comparison with published data. Their absolute configurations were assigned by the CD technique, applied for the first time to abietane diterpenes from Tripterygium wilfordii. Compound 2 is the first abietane‐type norditerpenoid isolated from the genus Tripterygium.