Premium
Synthesis and Evaluation of Four Hederagenin Glycosides as α ‐Glucosidase Inhibitor
Author(s) -
Liu QingChao,
Guo TianTian,
Guo ShouDong,
Li WenHong,
Li Dong
Publication year - 2013
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200128
Subject(s) - hederagenin , chemistry , glycoside , glycosylation , stereochemistry , biochemistry , triterpene , medicine , alternative medicine , pathology
The four hederagenin glycosides 1 – 4 were efficiently synthesized through one‐pot sequential glycosylations with glycose 1‐(trichloroacetimidate)s as donors, resulting in a significantly simplified synthetic procedure without isolation of glycosylation intermediates. The activity of the synthetic hederagenin glycosides 1 – 4 against α ‐glucosidase type IV was evaluated; hederagenin glycoside 4 containing an α ‐ L ‐rhamnopyranosyl unit showed the best activity with an IC 50 value of 47.9 μ M .
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom