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The First Stereoselective Total Synthesis of a Naturally Occurring Bioactive Diarylheptanoid, (3 R ,6 E )‐1,7‐Bis(4‐hydroxyphenyl)hept‐6‐en‐3‐ol, through Two Different Approaches
Author(s) -
Kashanna Jajula,
Jangili Paramesh,
Kumar Rathod Aravind,
Das Biswanath
Publication year - 2012
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201200084
Subject(s) - chemistry , kinetic resolution , stereoselectivity , wittig reaction , total synthesis , epoxide , stereochemistry , hydrolysis , olefin fiber , organic chemistry , enantioselective synthesis , catalysis
The stereoselective total synthesis of a naturally occurring bioactive diarylheptanoid, (3 R ,6 E )‐1,7‐bis(4‐hydroxyphenyl)hept‐6‐en‐3‐ol, has been accomplished starting from 4‐hydroxybenzaldehyde through two different approaches involving Wittig olefination, hydrolytic kinetic resolution of a racemic epoxide, and olefin cross‐metathesis reaction as the key steps.
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