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A Novel One‐Pot Synthesis of Fully Substituted Thiophen‐2(3 H )‐ones Using N,N ‐Disubstituted Thioamides
Author(s) -
ZaliBoeini Hassan,
Pourjafarian Fatemeh
Publication year - 2012
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201100517
Subject(s) - chemistry , base (topology) , chloride , aryl , medicinal chemistry , combinatorial chemistry , organic chemistry , mathematical analysis , alkyl , mathematics
A new one‐step synthesis of highly substituted thiophen‐2(3 H )‐one derivatives was developed. 2‐Aryl‐1‐(morpholin‐4‐yl)ethanethiones were reacted with 2‐chloro‐2‐phenylacetyl chloride in DMF in the presence of a base to give the title compounds in moderate‐to‐good yields.